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β-Casomorphin, Analogs and Fragments


Definition

Beta-Casomorphins are peptides resulting from the digestion of beta-Casein and vary from 4-11 amino acids in length1. They exhibit opioid or morphine-like functions1.

Discovery

ß-Casomorphins were first purified from casein digest of guinea pig ileum based on their ability to show opioid activity2.

Classification

ß-Casomorphins are opioid peptides1. Several naturally occurring ß-Casomorphins (BCM) have been identified: Bovine BCM-4, Bovine BCM-5, Bovine BCM-6, Bovine BCM-7, Bovine BCM-8, Bovine BCM-11, Human BCM-7, Human BCM-81. Several analogues which are structurally modified variants of naturally occurring BCMs have been synthesized1.