Oscar Pistorius, AKA "Blade Runner" -- the South African sprinter who uses carbon fiber prosthetics in place of the lower legs amputated as a child -- has officially lost his bid to run in the 2008 Olympics. He's going to give one last appeal to the International Association of Athletics Federations, but his chances of success are slim. The official reason, according to the BBC:

"...his prosthetic limbs give him an advantage over able-bodied opponents..."
For now, Pistorius' artificial legs make him fast, but still human-fast (he came in second at a recent meet); although his prosthetics reduce his energy requirements by 25%, he has yet to hit the qualifying speed for the 400m race. It's entirely possible that, even had the IAAF accepted his bid, he wouldn't have made it to this Olympics.
But it's also entirely possible that, in 2012, he'd be breaking records right and left. And shortly thereafter, he wouldn't be alone in doing so.