The Center for Strategic and International Studies (CSIS) also estimates that between 200,000 and 800,000 Israelis would be killed, the Jerusalem Post reported.
The report, which is theoretical and based on limited verified knowledge of Israel's and Iran's nuclear capability, paints a bleak picture for both nations.
It estimates that a nuclear war would last approximately three weeks and ultimately end with the annihilation of Iran, based on Israel's alleged possession of sophisticated and powerful nuclear weapons.
The report does not predict the number of deaths due to nuclear fallout.
It lists possible targets for an Iranian strike as Tel Aviv and Haifa, while the list of probable targets in Iran includes Tehran and Tabriz.