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Amastatin and Analogs


Definition

Amastatin is a oligopeptide antibiotic complex that is a competitive inhibitor of aminopeptidases and also has antitumor property.

Discovery

Amastatin was isolated from the culture filtrate of Streptomyces spME98-M31.

Analog of Amastatin

Epiamastatin is a diastereoepimer of the effective peptidase inhibitor amastatin and differs structurally by a single transposition of the OH group with H atom at C2. Compared with amastatin, epiamastatin is pharmacologically inactive.