The Great Filter: Consider our best-guess evolutionary path to an explosion which leads to visible colonization of most of the visible universe:
1. The right star system (including organics)
2. Reproductive something (e.g. RNA)
3. Simple (prokaryotic) single-cell life
4. Complex (archaeatic & eukaryotic) single-cell life
5. Sexual reproduction
6. Multi-cell life
7. Tool-using animals with big brains
8. Where we are now
9. [Interstellar] Colonization explosion